Formil peptidni receptor 1

Formil peptidni receptor 1
Identifikatori
Simboli FPR1; FMLP; FPR
Vanjski ID OMIM: 136537 MGI: 107443 HomoloGene: 20466 IUPHAR: FPR1 GeneCards: FPR1 Gene
Ontologija gena
Molekularna funkcija aktivnost rodopsinu-sličnog receptora
receptorska aktivnost
aktivnost N-formil peptidnog receptora
Celularna komponenta endozom
ćelijska membrana
integralno sa membranom
Biološki proces aktivacija MAPK aktivnosti
ćelijska motilnost
hemotaksa
inflamatorni respons
prenos signala
signalni put G-protein spregnutog receptora
G-protein signalizacija, spregnuta sa cAMP nukleotidnim sekundarnim glasnikom
azot oksidom posredovani prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2357 14293
Ensembl ENSG00000171051 ENSMUSG00000045551
UniProt P21462 Q3UV01
RefSeq (mRNA) NM_002029 NM_013521
RefSeq (protein) NP_002020 NP_038549
Lokacija (UCSC) Chr 19:
56.94 - 56.95 Mb
Chr 17:
17.58 - 17.59 Mb
PubMed pretraga [1] [2]

fMet-Leu-Phe receptor ili N-formil peptidni receptor je protein koji je kod ljudi kodiran FPR1 genom.[1][2][3]

Vidi još

  • Formil peptidni receptor

Literatura

  1. ^ Boulay F, Tardif M, Brouchon L, Vignais P (1990). „Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA”. Biochem Biophys Res Commun. 168 (3): 1103—9. PMID 2161213. doi:10.1016/0006-291X(90)91143-G. 
  2. ^ Zhang Y, Syed R, Uygar C, Pallos D, Gorry MC, Firatli E, Cortelli JR, VanDyke TE, Hart PS, Feingold E, Hart TC (2003). „Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients”. Genes Immun. 4 (1): 22—9. PMID 12595898. doi:10.1038/sj.gene.6363900. 
  3. ^ „Entrez Gene: FPR1 formyl peptide receptor 1”. 

Dodatna literatura

  • Graves V; Gabig T; McCarthy L; et al. (1992). „Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils.”. Blood. 80 (3): 776—87. PMID 1322204. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Murphy PM; Ozçelik T; Kenney RT; et al. (1992). „A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.”. J. Biol. Chem. 267 (11): 7637—43. PMID 1373134. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Perez HD; Holmes R; Kelly E; et al. (1992). „Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression.”. Biochemistry. 31 (46): 11595—9. PMID 1445895. doi:10.1021/bi00161a044. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Bao L; Gerard NP; Eddy RL; et al. (1992). „Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.”. Genomics. 13 (2): 437—40. PMID 1612600. doi:10.1016/0888-7543(92)90265-T. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Murphy PM, McDermott D (1991). „Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor.”. J. Biol. Chem. 266 (19): 12560—7. PMID 1712023. 
  • Boulay F, Tardif M, Brouchon L, Vignais P (1991). „The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.”. Biochemistry. 29 (50): 11123—33. PMID 2176894. doi:10.1021/bi00502a016. 
  • Wahl SM; Allen JB; Gartner S; et al. (1989). „HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.”. J. Immunol. 142 (10): 3553—9. PMID 2541200. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Jesaitis AJ; Naemura JR; Painter RG; et al. (1983). „Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes.”. Biochim. Biophys. Acta. 719 (3): 556—68. PMID 6129903. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Prossnitz ER, Kim CM, Benovic JL, Ye RD (1995). „Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2.”. J. Biol. Chem. 270 (3): 1130—7. PMID 7836371. doi:10.1074/jbc.270.3.1130. 
  • Klotz KN, Jesaitis AJ (1994). „Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization.”. Biochem. Pharmacol. 48 (6): 1297—300. PMID 7945424. doi:10.1016/0006-2952(94)90168-6. 
  • Bommakanti RK, Dratz EA, Siemsen DW, Jesaitis AJ (1994). „Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity.”. Biochim. Biophys. Acta. 1209 (1): 69—76. PMID 7947984. doi:10.1016/0167-4838(94)90138-4. 
  • Murphy PM, Tiffany HL, McDermott D, Ahuja SK (1993). „Sequence and organization of the human N-formyl peptide receptor-encoding gene.”. Gene. 133 (2): 285—90. PMID 8224916. doi:10.1016/0378-1119(93)90653-K. 
  • Jesaitis AJ; Erickson RW; Klotz KN; et al. (1993). „Functional molecular complexes of human N-formyl chemoattractant receptors and actin.”. J. Immunol. 151 (10): 5653—65. PMID 8228254. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Särndahl E; Bokoch GM; Boulay F; et al. (1996). „Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton.”. J. Biol. Chem. 271 (25): 15267—71. PMID 8663057. doi:10.1074/jbc.271.25.15267. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Maestes DC, Potter RM, Prossnitz ER (1999). „Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.”. J. Biol. Chem. 274 (42): 29791—5. PMID 10514456. doi:10.1074/jbc.274.42.29791. 
  • Liang TS, Wang JM, Murphy PM, Gao JL (2000). „Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils.”. Biochem. Biophys. Res. Commun. 270 (2): 331—5. PMID 10753626. doi:10.1006/bbrc.2000.2416. 
  • Luu NT, Rainger GE, Nash GB (2000). „Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.”. J. Immunol. 164 (11): 5961—9. PMID 10820279. 
  • Bennett TA, Maestas DC, Prossnitz ER (2000). „Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence.”. J. Biol. Chem. 275 (32): 24590—4. PMID 10823817. doi:10.1074/jbc.C000314200. 
  • Ayala JM; Goyal S; Liverton NJ; et al. (2000). „Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway.”. J. Leukoc. Biol. 67 (6): 869—75. PMID 10857861. CS1 одржавање: Експлицитна употреба et al. (веза)
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Klasa A: Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
Neuropeptidni
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
Orfan
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
Orfan
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
Ukus
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni