蛋白酪氨酸磷酸酶C型受體 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Protein_PTPRC_PDB_1ygr.png/250px-Protein_PTPRC_PDB_1ygr.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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1YGU、1YGR、5FMV、5FN6、5FN7 |
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識別號 |
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别名 | PTPRC;, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C |
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外部ID | OMIM:151460 MGI:97810 HomoloGene:2126 GeneCards:PTPRC |
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相關疾病 |
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溃疡性结肠炎[1] |
基因位置(人类) |
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![1號染色體](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | 染色体 | 1號染色體[2] |
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| 基因座 | 1q31.3-q32.1 | 起始 | 198,638,457 bp[2] |
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终止 | 198,757,476 bp[2] |
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基因位置(小鼠) |
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![小鼠1号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/260px-Ideogram_house_mouse_chromosome_1.svg.png) | 染色体 | 小鼠1号染色体[3] |
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| 基因座 | 1 E4|1 60.73 cM | 起始 | 137,990,599 bp[3] |
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终止 | 138,103,446 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/74/PBB_GE_PTPRC_212588_at_fs.png/250px-PBB_GE_PTPRC_212588_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/7/72/PBB_GE_PTPRC_212587_s_at_fs.png/250px-PBB_GE_PTPRC_212587_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/6/6b/PBB_GE_PTPRC_207238_s_at_fs.png/250px-PBB_GE_PTPRC_207238_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • phosphoprotein phosphatase activity • phosphatase activity • 血浆蛋白结合 • transmembrane receptor protein tyrosine phosphatase activity • protein kinase binding • 水解酶活性 • protein tyrosine phosphatase activity
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細胞組分 | • integral component of membrane • 膜 • 粘着斑 • 细胞膜 • integral component of plasma membrane • cell surface • 脂筏模型 • 外排體 • external side of plasma membrane • secretory granule membrane
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生物學過程 | • B cell receptor signaling pathway • cell cycle phase transition • release of sequestered calcium ion into cytosol • negative regulation of protein kinase activity • bone marrow development • stem cell development • 蛋白质去磷酸化 • negative regulation of cytokine-mediated signaling pathway • positive regulation of hematopoietic stem cell migration • regulation of cell cycle • negative regulation of cell adhesion involved in substrate-bound cell migration • negative regulation of T cell mediated cytotoxicity • cell surface receptor signaling pathway • B cell proliferation • T cell differentiation • positive regulation of B cell proliferation • defense response to virus • positive regulation of T cell proliferation • hematopoietic progenitor cell differentiation • positive regulation of antigen receptor-mediated signaling pathway • T cell receptor signaling pathway • positive regulation of stem cell proliferation • 去磷酸化 • positive regulation of protein kinase activity • peptidyl-tyrosine dephosphorylation • neutrophil degranulation
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | |
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ENSG00000081237 ENSG00000262418 |
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UniProt | | |
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mRNA序列 | |
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NM_001267798 NM_002838 NM_080921 NM_080922 |
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NM_001111316 NM_001268286 NM_011210 |
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蛋白序列 | |
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NP_001254727 NP_002829 NP_563578 NP_563578.2 NP_002829.3 |
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NP_001104786 NP_001255215 NP_035340 |
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基因位置(UCSC) | Chr 1: 198.64 – 198.76 Mb | Chr 1: 137.99 – 138.1 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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