CD61 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f4/Protein_ITGB3_PDB_1jv2.png/250px-Protein_ITGB3_PDB_1jv2.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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4O02、1JV2、1KUP、1KUZ、1L5G、1M1X、1M8O、1MIZ、1MK7、1MK9、1S4X、1TYE、1U8C、2K9J、2KNC、2KV9、2L1C、2L91、2LJD、2LJE、2LJF、2MTP、2Q6W、2RMZ、2RN0、2VC2、2VDK、2VDL、2VDM、2VDN、2VDP、2VDQ、2VDR、3FCS、3FCU、3IJE、3NID、3NIF、3NIG、3T3M、3T3P、3ZDX、3ZDY、3ZDZ、3ZE0、3ZE1、3ZE2、4CAK、4G1E、4G1M、4MMX、4MMY、4MMZ、5HDB、4Z7Q、4Z7O、4Z7N |
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識別號 |
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别名 | ITGB3;, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2 |
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外部ID | OMIM:173470 MGI:96612 HomoloGene:55444 GeneCards:ITGB3 |
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相關疾病 |
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血小板无力症、platelet-type bleeding disorder 16[1] |
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為以下藥物的標靶 |
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cilengitide、依非巴特、tirofiban hydrochloride hydrate[2] |
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基因位置(小鼠) |
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![小鼠11号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | 染色体 | 小鼠11号染色体[4] |
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| 基因座 | 11 E1|11 67.84 cM | 起始 | 104,498,826 bp[4] |
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终止 | 104,561,302 bp[4] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/71/PBB_GE_ITGB3_204628_s_at_fs.png/250px-PBB_GE_ITGB3_204628_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/d/dc/PBB_GE_ITGB3_204625_s_at_fs.png/250px-PBB_GE_ITGB3_204625_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/2/20/PBB_GE_ITGB3_204626_s_at_fs.png/250px-PBB_GE_ITGB3_204626_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • vascular endothelial growth factor receptor 2 binding • fibronectin binding • virus receptor activity • extracellular matrix binding • protein disulfide isomerase activity • 蛋白酶結合 • platelet-derived growth factor receptor binding • 血浆蛋白结合 • 相同蛋白质结合 • 酶结合 • cell adhesion molecule binding • neuregulin binding • coreceptor activity • fibroblast growth factor binding • insulin-like growth factor I binding • C-X3-C chemokine binding • integrin binding • fibrinogen binding
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細胞組分 | • integral component of membrane • cell projection • alphav-beta3 integrin-vitronectin complex • 膜 • 粘着斑 • 黑色素体 • receptor complex • 细胞膜 • integral component of plasma membrane • ruffle membrane • cell surface • 细胞连接 • integrin complex • platelet alpha granule membrane • integrin alphav-beta3 complex • 外排體 • lamellipodium membrane • 细胞核 • microvillus membrane • filopodium membrane • alphav-beta3 integrin-IGF-1-IGF1R complex • alphav-beta3 integrin-PKCalpha complex • alphav-beta3 integrin-HMGB1 complex • glutamatergic synapse • 突触
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生物學過程 | • negative regulation of lipoprotein metabolic process • apolipoprotein A-I-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of protein phosphorylation • regulation of cell migration • negative chemotaxis • positive regulation of endothelial cell proliferation • tube development • heterotypic cell-cell adhesion • angiogenesis involved in wound healing • 傷口癒合 • platelet degranulation • 凝血 • extracellular matrix organization • smooth muscle cell migration • positive regulation of endothelial cell migration • 增殖 • cell-substrate adhesion • vascular endothelial growth factor receptor signaling pathway • 細胞粘附 • positive regulation of peptidyl-tyrosine phosphorylation • mesodermal cell differentiation • cell-substrate junction assembly • integrin-mediated signaling pathway • negative regulation of lipid storage • substrate adhesion-dependent cell spreading • negative regulation of lipid transport • cell-matrix adhesion • viral process • regulation of bone resorption • platelet aggregation • 细胞迁移 • negative regulation of macrophage derived foam cell differentiation • activation of protein kinase activity • leukocyte migration • cell adhesion mediated by integrin • platelet activation • apoptotic cell clearance • regulation of postsynaptic neurotransmitter receptor internalization • regulation of protein localization • regulation of serotonin uptake
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 17: 47.25 – 47.31 Mb | Chr 11: 104.5 – 104.56 Mb |
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PubMed查找 | [5] | [6] |
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維基數據 |
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