朊毒體蛋白 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/8/84/PRNP_.png/250px-PRNP_.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2OL9、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NHD、3NVF、4DGI、4E1H、4E1I,%%s1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2M8T、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NVF、4DGI、4E1H、4E1I、4KML、4N9O |
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識別號 |
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别名 | PRNP;, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein |
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外部ID | OMIM:176640 MGI:97769 HomoloGene:7904 GeneCards:PRNP |
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相關疾病 |
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傳染性海綿狀腦病、克雅二氏病、致死性家族失眠症、Gerstmann–Sträussler–Scheinker症候群、Huntington disease-like 1、spongiform encephalopathy with neuropsychiatric features、inherited Creutzfeldt–Jakob disease[1] |
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基因位置(小鼠) |
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![小鼠2号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | 染色体 | 小鼠2号染色体[3] |
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| 基因座 | 2 F2|2 64.07 cM | 起始 | 131,751,848 bp[3] |
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终止 | 131,780,349 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/77/PBB_GE_PRNP_215707_s_at_fs.png/250px-PBB_GE_PRNP_215707_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_PRNP_201300_s_at_fs.png/250px-PBB_GE_PRNP_201300_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • chaperone binding • transmembrane transporter binding • microtubule binding • ATP-dependent protein binding • 金屬離子結合 • tubulin binding • 血浆蛋白结合 • 相同蛋白质结合 • copper ion binding • lamin binding • amyloid-beta binding • 蛋白酶結合 • glycosaminoglycan binding • type 5 metabotropic glutamate receptor binding • type 8 metabotropic glutamate receptor binding • signaling receptor activity • 大分子复合物结合 • cupric ion binding • cuprous ion binding
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細胞組分 | • mitochondrial outer membrane • 膜 • 線粒體 • integral component of membrane • 細胞質 • 高尔基体 • 细胞膜 • cell surface • 内质网 • 脂筏模型 • anchored component of membrane • 外排體 • 细胞核 • extrinsic component of membrane • 细胞质基质 • 突触后致密物质 • 包涵体 • 树突 • anchored component of external side of plasma membrane • 核膜 • 細胞內膜結合細胞器 • postsynapse
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生物學過程 | • negative regulation of protein phosphorylation • negative regulation of interferon-gamma production • response to cadmium ion • negative regulation of calcineurin-NFAT signaling cascade • response to copper ion • negative regulation of apoptotic process • response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of T cell receptor signaling pathway • regulation of protein localization • negative regulation of activated T cell proliferation • 学习和记忆 • cellular copper ion homeostasis • cellular response to copper ion • 細胞週期 • 代謝 • negative regulation of interleukin-17 production • protein homooligomerization • negative regulation of interleukin-2 production • regulation of potassium ion transmembrane transport • 长期记忆 • positive regulation of cell death • negative regulation of protein processing • protein destabilization • activation of protein kinase activity • calcium-mediated signaling using intracellular calcium source • negative regulation of catalytic activity • positive regulation of neuron apoptotic process • regulation of peptidyl-tyrosine phosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • positive regulation of protein targeting to membrane • dendritic spine maintenance • negative regulation of long-term synaptic potentiation • regulation of glutamate receptor signaling pathway • positive regulation of neuron death • negative regulation of amyloid-beta formation • regulation of intracellular calcium activated chloride channel activity • negative regulation of dendritic spine maintenance • negative regulation of amyloid precursor protein catabolic process • positive regulation of protein localization to plasma membrane • response to amyloid-beta • cellular response to amyloid-beta • regulation of calcium ion import across plasma membrane • neuron projection maintenance
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | NM_183079 NM_000311 NM_001080121 NM_001080122 NM_001080123
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NM_001271561 |
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蛋白序列 | NP_000302 NP_001073590 NP_001073591 NP_001073592 NP_001258490
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NP_898902 NP_000302.1 NP_001073590.1 NP_001073591.1 NP_001073592.1 NP_898902.1 |
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基因位置(UCSC) | Chr 20: 4.69 – 4.7 Mb | Chr 2: 131.75 – 131.78 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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