CD44 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Protein_CD44_PDB_1poz.png/250px-Protein_CD44_PDB_1poz.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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1POZ、1UUH、2I83、4PZ3、4PZ4 |
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識別號 |
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别名 | CD44;, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group) |
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外部ID | OMIM:107269 MGI:88338 HomoloGene:508 GeneCards:CD44 |
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基因位置(小鼠) |
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![小鼠2号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | 染色体 | 小鼠2号染色体[2] |
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| 基因座 | 2 E2|2 54.13 cM | 起始 | 102,641,486 bp[2] |
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终止 | 102,732,010 bp[2] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/PBB_GE_CD44_204490_s_at_fs.png/250px-PBB_GE_CD44_204490_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/PBB_GE_CD44_212063_at_fs.png/250px-PBB_GE_CD44_212063_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/PBB_GE_CD44_204489_s_at_fs.png/250px-PBB_GE_CD44_204489_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • collagen binding • 血浆蛋白结合 • hyaluronic acid binding • cytokine receptor activity • transmembrane signaling receptor activity
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細胞組分 | • integral component of membrane • 高尔基体 • macrophage migration inhibitory factor receptor complex • 膜 • 粘着斑 • 细胞膜 • integral component of plasma membrane • cell surface • 外排體 • 细胞质基质 • secretory granule membrane • apical plasma membrane • lamellipodium membrane • cell projection • 微绒毛 • basolateral plasma membrane
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生物學過程 | • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • monocyte aggregation • positive regulation of heterotypic cell-cell adhesion • hyaluronan catabolic process • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • interferon-gamma-mediated signaling pathway • extracellular matrix disassembly • extracellular matrix organization • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-serine phosphorylation • 軟骨生成 • 細胞粘附 • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell-matrix adhesion • positive regulation of monocyte aggregation • leukocyte migration • neutrophil degranulation • wound healing, spreading of cells • regulation of lamellipodium morphogenesis • cell-cell adhesion • inflammatory response • 细胞迁移 • T细胞活化 • positive regulation of kinase activity
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392
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NM_001202555 NM_001202556 NM_001202557 |
| NM_001039150 NM_001039151 NM_001177785 NM_001177786 NM_001177787
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NM_009851 |
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蛋白序列 | NP_000601 NP_001001389 NP_001001390 NP_001001391 NP_001001392
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NP_001189484 NP_001189485 NP_001189486 |
| NP_001034239 NP_001034240 NP_001171256 NP_001171257 NP_001171258
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NP_033981 |
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基因位置(UCSC) | Chr 11: 35.14 – 35.23 Mb | Chr 2: 102.64 – 102.73 Mb |
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PubMed查找 | [3] | [4] |
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維基數據 |
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