細胞程式死亡-配體1 |
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已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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3BIK、3BIS、3FN3、3SBW、4Z18、4ZQK、5C3T、5J89、5J8O |
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識別號 |
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别名 | CD274;, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, CD274 molecule, Programmed cell death ligand 1, hPD-L1 |
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外部ID | OMIM:605402 MGI:1926446 HomoloGene:8560 GeneCards:CD274 |
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為以下藥物的標靶 |
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度伐魯單抗[1] |
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基因本體 |
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分子功能 | • 血浆蛋白结合
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細胞組分 | • integral component of membrane • 膜 • cell surface • 外排體 • external side of plasma membrane • 內膜系統 • 细胞膜 • early endosome membrane • recycling endosome membrane • 核内体
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生物學過程 | • negative regulation of interleukin-10 production • response to cytokine • negative regulation of interferon-gamma production • negative regulation of tumor necrosis factor superfamily cytokine production • positive regulation of cell migration • T cell costimulation • toxin transport • negative regulation of activated T cell proliferation • regulation of activated T cell proliferation • cell surface receptor signaling pathway • negative regulation of T cell proliferation • regulation of T cell apoptotic process • 免疫反应 • positive regulation of T cell proliferation • 訊息傳遞 • regulation of activated CD4-positive, alpha-beta T cell apoptotic process • positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process • positive regulation of tolerance induction to tumor cell • negative regulation of CD8-positive, alpha-beta T cell activation • immune system process • negative regulation of CD4-positive, alpha-beta T cell proliferation • cellular response to lipopolysaccharide • adaptive immune response
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | |
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NM_001314029 NM_001267706 NM_014143 |
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蛋白序列 | |
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NP_001254635 NP_001300958 NP_054862 |
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基因位置(UCSC) | Chr 9: 5.45 – 5.47 Mb | Chr 19: 29.34 – 29.37 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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