SR-142,948
IUPAC ime | |
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2-([5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino)adamantane-2-carboxylic acid | |
Identifikatori | |
CAS broj | 184162-64-9 |
PubChem | CID 5311451 |
IUPHAR/BPS | 1580 |
ChemSpider | 4470937 Y |
Hemijski podaci | |
Formula | C39H51N5O6 |
Molarna masa | 685.850 g/mol |
SMILES
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InChI
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SR-142,948 je lek koji se koristi u naučnim istraživanjima. On pripada grupi nepeptidnih antagonista selektivnih za neurotenzinske receptore, mada nije selektivan za specifični tip tog receptora.[1] On je korišten u izučavanju uloge neurotenzina u regulaciji aktivnosti dopaminskog receptora[2][3][4][5] i glutamatne signalizacije u mozgu.[6][7] U životinjskim studies SR-142,948 blokira efekte stimulanata,[8] kao što je MDMA.[9]
Reference
- ^ Nalivaiko E, Michaud JC, Soubrié P, Le Fur G (1998). „Electrophysiological evidence for putative subtypes of neurotensin receptors in guinea-pig mesencephalic dopaminergic neurons”. Neuroscience. 86 (3): 799—811. PMID 9692718. doi:10.1016/S0306-4522(98)00084-0.
- ^ Alonso R, Gnanadicom H, Fréchin N, Fournier M, Le Fur G, Soubrié P (1999). „Blockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain”. The European Journal of Neuroscience. 11 (3): 967—74. PMID 10103090. doi:10.1046/j.1460-9568.1999.00506.x. [мртва веза]
- ^ Matsuyama S, Higashi H, Maeda H, Greengard P, Nishi A (2002). „Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors”. Journal of Neurochemistry. 81 (2): 325—34. PMID 12064480. doi:10.1046/j.1471-4159.2002.00822.x. [мртва веза]
- ^ Leonetti M, Brun P, Sotty F, Steinberg R, Soubrié P, Bert L, Renaud B, Suaud-Chagny MF (2002). „The neurotensin receptor antagonist SR 142948A blocks the efflux of dopamine evoked in nucleus accumbens by neurotensin ejection into the ventral tegmental area”. Naunyn-Schmiedeberg's Archives of Pharmacology. 365 (6): 427—33. PMID 12070755. doi:10.1007/s00210-002-0574-6.
- ^ Panayi F, Colussi-Mas J, Lambás-Señas L, Renaud B, Scarna H, Bérod A (2005). „Endogenous neurotensin in the ventral tegmental area contributes to amphetamine behavioral sensitization”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30 (5): 871—9. PMID 15637639. doi:10.1038/sj.npp.1300638.
- ^ Matsuyama S, Fukui R, Higashi H, Nishi A (2003). „Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling”. The European Journal of Neuroscience. 18 (5): 1247—53. PMID 12956723. doi:10.1046/j.1460-9568.2003.02859.x. [мртва веза]
- ^ Yin HH, Adermark L, Lovinger DM (2008). „Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling”. Neuropharmacology. 54 (1): 79—86. PMC 2697967 . PMID 17675102. doi:10.1016/j.neuropharm.2007.06.004.
- ^ Reynolds SM, Geisler S, Bérod A, Zahm DS (2006). „Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area”. The European Journal of Neuroscience. 24 (1): 188—96. PMID 16882016. doi:10.1111/j.1460-9568.2006.04791.x.
- ^ Marie-Claire C, Palminteri S, Romualdi P, Noble F (2008). „Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice”. Neuropharmacology. 54 (7): 1107—11. PMID 18410947. doi:10.1016/j.neuropharm.2008.03.001.
Spoljašnje veze
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Neuropeptidni ligandi
CCKA | Agonisti: Holecistokinin • CCK-4 Antagonisti: Asperlicin • Proglumid • Lorglumid • Devazepid • Deksloksiglumid |
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CCKB |
CRF1 | |
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CRF2 | Agonisti: Kortikotropin-oslobađajuči hormon |
GAL1 | |
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GAL2 | |
GAL3 |
MCH1 | Agonisti: Melanin-koncentrirajući hormon Antagonisti: ATC-0175 • GW-803,430 • NGD-4715 • SNAP-7941 • SNAP-94847 |
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MCH2 | Agonisti: Melanin-koncentrirajući hormon |
MC1 | |
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MC2 | |
MC3 | |
MC4 | |
MC5 | Agonisti: alfa-MSH • Melanotan II |
Y1 | |
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Y2 | |
Y4 | |
Y5 |
NTS1 | |
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NTS2 |
vidi Opioidi
OX1 | |
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OX2 |
Agonisti: Karbetocin • Demoksitocin • Oksitocin • WAY-267,464
Antagonisti: Atosiban • L-371,257 • L-368,899
Antagonisti: Atosiban • L-371,257 • L-368,899
NK1 | Agonisti: Supstanca P Antagonisti: Aprepitant • Befetupitant • Kasopitant • CI-1021 • CP-96,345 • CP-99,994 • CP-122,721 • Dapitant • Ezlopitant • FK-888 • Fosaprepitant • GR-203,040 • GW-597,599 • HSP-117 • L-733,060 • L-741,671 • L-743,310 • L-758,298 • Lanepitant • LY-306,740 • Maropitant • Netupitant • NKP-608 • Nolpitantium • Orvepitant • RP-67,580 • SDZ NKT 343 • Vestipitant • Vofopitant |
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NK2 | |
NK3 |
V1A | Agonisti: Dezmopresin • Felipresin • Ornipresin • Terlipresin • Vazopresin Antagonisti: Konivaptan • Demeklociklin • Relkovaptan |
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V1B | |
V2 | Agonisti: Dezmopresin • Ornipresin • Vazopresin Antagonisti: Konivaptan • Demeklociklin • Liksivaptan • Mozavaptan • Satavaptan • Tolvaptan |
Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |