GPR132

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G protein-spregnuti receptor 132
Identifikatori
SimboliGPR132; G2A; MGC99642
Vanjski IDOMIM: 606167 MGI: 1890220 HomoloGene: 8350 IUPHAR: GPR132 GeneCards: GPR132 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • G1/S prenos mitotičkog ćelijskog ciklusa
• prenos signal
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez2993356696
EnsemblENSG00000183484ENSMUSG00000021298
UniProtQ9UNW8Q0VBS4
RefSeq (mRNA)NM_013345NM_019925
RefSeq (protein)NP_037477NP_064309
Lokacija (UCSC)Chr 14:
104.59 - 104.6 Mb		Chr 12:
113.3 - 113.31 Mb
PubMed pretraga[1][2]

GPR132, G protein-spregnuti receptor 132, je protein koji je kod čoveka kodiran GPR132 genom.[1][2]

GPR132 je receptor visokog afiniteta za lizofosfatidilholin (LPC), jednu od fosfolipidnih komponenti oksidovanih lipoproteina niske gustine. Ovaj protein može da reaguje na promenu LPC nivoa na mestima zapaljenja i da ograniči ekspanziju ćelija ćelija koje infiltriraju tkivo. Sličan protein kod miša učestvuje u progresiji ćelijskog cilusa.[2]

Povezano

Literatura

  1. ↑ Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON (Jun 2002). „Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene”. Cancer Cell 1 (4): 381–91. DOI:10.1016/S1535-6108(02)00058-2. PMID 12086852. 
  2. ↑ 2,0 2,1 „Entrez Gene: GPR132 G protein-coupled receptor 132”. PMID 29933. 

Dodatna literatura

  • Weng Z, Fluckiger AC, Nisitani S, et al. (1998). „A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.”. Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334–9. DOI:10.1073/pnas.95.21.12334. PMC 22832. PMID 9770487. 
  • Kabarowski JH, Zhu K, Le LQ, et al. (2001). „Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.”. Science 293 (5530): 702–5. DOI:10.1126/science.1061781. PMID 11474113. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Rikitake Y, Hirata K, Yamashita T, et al. (2002). „Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.”. Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049–53. DOI:10.1161/01.ATV.0000040598.18570.54. PMID 12482833. 
  • Lin P, Ye RD (2003). „The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.”. J. Biol. Chem. 278 (16): 14379–86. DOI:10.1074/jbc.M209101200. PMID 12586833. 
  • Lum H, Qiao J, Walter RJ, et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. DOI:10.1152/ajpheart.00359.2003. PMID 12805023. 
  • Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). „G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.”. J. Biol. Chem. 279 (41): 42484–91. DOI:10.1074/jbc.M406561200. PMID 15280385. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Witte ON, Kabarowski JH, Xu Y, et al. (2005). „Retraction.”. Science 307 (5707): 206. DOI:10.1126/science.307.5707.206b. PMID 15653487. 
  • Radu CG, Nijagal A, McLaughlin J, et al. (2005). „Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.”. Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. DOI:10.1073/pnas.0409415102. PMC 545089. PMID 15665078. 
  • Obinata H, Hattori T, Nakane S, et al. (2006). „Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.”. J. Biol. Chem. 280 (49): 40676–83. DOI:10.1074/jbc.M507787200. PMID 16236715. 
  • Frasch SC, Zemski-Berry K, Murphy RC, et al. (2007). „Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.”. J. Immunol. 178 (10): 6540–8. PMID 17475884. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)