LPAR6

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Receptor lizofosfatidne kiseline 6
Identifikatori
SimboliLPAR6; MGC120358; P2Y5; P2RY5
Vanjski IDOMIM: 609239 MGI: 1914418 HomoloGene: 55925 IUPHAR: GeneCards: LPAR6 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost purinskog nukleotidnog receptora, G-protein spregnuti
Celularna komponenta • membrana
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez1016167168
EnsemblENSG00000139679ENSMUSG00000033446
UniProtP43657Q8BMC0
RefSeq (mRNA)NM_005767NM_175116
RefSeq (protein)NP_005758NP_780325
Lokacija (UCSC)Chr 13:
47.88 - 47.89 Mb		Chr 14:
71.97 - 71.97 Mb
PubMed pretraga[1][2]

LPAR6 (receptor lizofosfatidne kiseline 6, LPA6, P2RY5) je protein je protein koji je kod ljudi kodiran LPAR6 genom.[1][2][3][4] LPA6 je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).[5][6]

Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktivirani nukleotidima adenozina i uridina.[4]

Uloga u rastu/gubitku kose

Februara 2008 istraživači sa Bonskog univerziteta su objavili da su pronašli genetsku osnovu za dva oblika naslednog gubitka kose. Oni su utvrdili da gen P2RY5 uzrokuje retku, naslednu formu gubitka kose koja se naziva Hypotrichosis simplex. To je bio prvi humani receptor za koji je poznato da učestvuje u rastu kose.[5]

Povezano

Reference

  1. ↑ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells”. Biochim Biophys Acta 1492 (1): 127–38. PMID 11004484. 
  2. ↑ Ralevic V, Burnstock G (Nov 1998). „Receptors for purines and pyrimidines”. Pharmacol Rev 50 (3): 413–92. PMID 9755289. 
  3. ↑ Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S (Jun 2009). „Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6”. J Biol Chem 284 (26): 17731–41. DOI:10.1074/jbc.M808506200. PMC 2719412. PMID 19386608. 
  4. ↑ 4,0 4,1 „Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5”. 
  5. ↑ 5,0 5,1 Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC (March 2008). „G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth”. Nat. Genet. 40 (3): 329–34. DOI:10.1038/ng.84. PMID 18297070. 
  6. ↑ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology 50 (1): 157–186. DOI:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. [mrtav link]

Literatura

  • Toguchida J, McGee TL, Paterson JC, et al. (1993). „Complete genomic sequence of the human retinoblastoma susceptibility gene.”. Genomics 17 (3): 535–43. DOI:10.1006/geno.1993.1368. PMID 7902321. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1-2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Herzog H, Darby K, Hort YJ, Shine J (1997). „Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene.”. Genome Res. 6 (9): 858–61. DOI:10.1101/gr.6.9.858. PMID 8889552. 
  • Li Q, Schachter JB, Harden TK, Nicholas RA (1997). „The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.”. Biochem. Biophys. Res. Commun. 236 (2): 455–60. DOI:10.1006/bbrc.1997.6984. PMID 9240460. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene 200 (1-2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). „The DNA sequence and analysis of human chromosome 13.”. Nature 428 (6982): 522–8. DOI:10.1038/nature02379. PMC 2665288. PMID 15057823. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Ihara H, Hirukawa K, Goto S, Togari A (2005). „ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts.”. Biochem. Biophys. Res. Commun. 326 (2): 329–34. DOI:10.1016/j.bbrc.2004.11.037. PMID 15582581. 
  • p
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  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)