LPAR4
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Receptor lizofosfatidne kiseline 4 | |||||||||||
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Identifikatori | |||||||||||
Simboli | LPAR4; GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9 | ||||||||||
Vanjski ID | OMIM: 300086 MGI: 1925384 HomoloGene: 3871 IUPHAR: GeneCards: LPAR4 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 2846 | 78134 | |||||||||
Ensembl | ENSG00000147145 | ENSMUSG00000049929 | |||||||||
UniProt | Q99677 | Q80UD5 | |||||||||
RefSeq (mRNA) | NM_005296 | NM_175271 | |||||||||
RefSeq (protein) | NP_005287 | NP_780480 | |||||||||
Lokacija (UCSC) | Chr X: 77.9 - 77.9 Mb | Chr X: 103.12 - 103.14 Mb | |||||||||
PubMed pretraga | [1] | [2] |
LPAR4, receptor lizofosfatidne kiseline 4 ili LPA4, je protein koji je kod čoveka kodiran LPAR4 genom.[1][2][3] LPA4 je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).[4]
Povezano
- Lizofosfolipidni receptor
- P2Y receptor
Reference
- ↑ „Entrez Gene: GPR23 G protein-coupled receptor 23”.
- ↑ Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). „Cloning of a human heptahelical receptor closely related to the P2Y5 receptor”. Biochem. Biophys. Res. Commun. 236 (1): 106–12. DOI:10.1006/bbrc.1997.6895. PMID 9223435.
- ↑ O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). „Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes”. Gene 187 (1): 75–81. DOI:10.1016/S0378-1119(96)00722-6. PMID 9073069.
- ↑ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology 50 (1): 157–186. DOI:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. [mrtav link]
Literatura
- Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.”. Biochim. Biophys. Acta 1492 (1): 127–38. PMID 11004484.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Noguchi K, Ishii S, Shimizu T (2003). „Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.”. J. Biol. Chem. 278 (28): 25600–6. DOI:10.1074/jbc.M302648200. PMID 12724320.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). „The DNA sequence of the human X chromosome.”. Nature 434 (7031): 325–37. DOI:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). „Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”. J. Proteome Res. 4 (6): 2070–80. DOI:10.1021/pr0502065. PMC 1850943. PMID 16335952.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)