KLF4 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/KLF4_prot.png/250px-KLF4_prot.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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識別號 |
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别名 | KLF4;, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4 |
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外部ID | OMIM:602253 MGI:1342287 HomoloGene:3123 GeneCards:KLF4 |
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基因位置(人类) |
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![9號染色體](//upload.wikimedia.org/wikipedia/commons/thumb/d/de/Ideogram_human_chromosome_9.svg/300px-Ideogram_human_chromosome_9.svg.png) | 染色体 | 9號染色體[1] |
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| 基因座 | 9q31.2 | 起始 | 107,484,852 bp[1] |
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终止 | 107,490,482 bp[1] |
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基因位置(小鼠) |
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![小鼠4号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | 染色体 | 小鼠4号染色体[2] |
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| 基因座 | 4 B3|4 29.76 cM | 起始 | 55,527,143 bp[2] |
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终止 | 55,532,466 bp[2] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/78/PBB_GE_KLF4_221841_s_at_fs.png/250px-PBB_GE_KLF4_221841_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/4/4d/PBB_GE_KLF4_220266_s_at_fs.png/250px-PBB_GE_KLF4_220266_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • DNA结合 • sequence-specific DNA binding • beta-catenin binding • phosphatidylinositol 3-kinase regulator activity • DNA结合转录因子活性 • 鋅離子結合 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • 核心启动子近端区域序列特异性DNA结合 • 金屬離子結合 • RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity • 血浆蛋白结合 • nucleic acid binding • double-stranded DNA binding • promoter-specific chromatin binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription coregulator binding • histone deacetylase binding
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細胞組分 | • 細胞質 • 轉錄調節複合物 • 核质 • 染色质 • 细胞核
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生物學過程 | • negative regulation of chemokine (C-X-C motif) ligand 2 production • epidermal cell differentiation • cellular response to retinoic acid • negative regulation of protein kinase B signaling • negative regulation of muscle hyperplasia • 平滑肌細胞增殖的負調控 • positive regulation of protein metabolic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of axon regeneration • cellular response to peptide • regulation of transcription, DNA-templated • positive regulation of hemoglobin biosynthetic process • response to retinoic acid • somatic stem cell population maintenance • cellular response to laminar fluid shear stress • regulation of transcription by RNA polymerase II • 细胞分化 • epidermis morphogenesis • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • cellular response to organic cyclic compound • post-embryonic hemopoiesis • negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • response to organic substance • negative regulation of gene expression • negative regulation of response to cytokine stimulus • transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • negative regulation of phosphatidylinositol 3-kinase signaling • stem cell population maintenance • negative regulation of cell migration involved in sprouting angiogenesis • positive regulation of gene expression • negative regulation of cell migration • regulation of cell population proliferation • post-embryonic camera-type eye development • regulation of phosphatidylinositol 3-kinase activity • positive regulation of telomerase activity • canonical Wnt signaling pathway • negative regulation of ERK1 and ERK2 cascade • regulation of cell differentiation • mesodermal cell fate determination • negative regulation of heterotypic cell-cell adhesion • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • cellular response to cycloheximide • negative regulation of inflammatory response • fat cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • cellular response to hydrogen peroxide • negative regulation of leukocyte adhesion to arterial endothelial cell • positive regulation of core promoter binding • cellular response to leukemia inhibitory factor • negative regulation of angiogenesis • pri-miRNA transcription by RNA polymerase II • negative regulation of G1/S transition of mitotic cell cycle • positive regulation of transcription, DNA-templated • positive regulation of sprouting angiogenesis
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 9: 107.48 – 107.49 Mb | Chr 4: 55.53 – 55.53 Mb |
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PubMed查找 | [3] | [4] |
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維基數據 |
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