ZEB1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Protein_ZEB1_PDB_2e19.png/250px-Protein_ZEB1_PDB_2e19.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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識別號 |
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别名 | ZEB1;, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A |
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外部ID | OMIM:189909 MGI:1344313 HomoloGene:31779 GeneCards:ZEB1 |
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相關疾病 |
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富克斯营养不良[1] |
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基因位置(小鼠) |
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![小鼠18号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/260px-Ideogram_house_mouse_chromosome_18.svg.png) | 染色体 | 小鼠18号染色体[3] |
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| 基因座 | 18 4.42 cM|18 A1 | 起始 | 5,591,860 bp[3] |
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终止 | 5,775,467 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/2/23/PBB_GE_ZEB1_210875_s_at_fs.png/250px-PBB_GE_ZEB1_210875_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b8/PBB_GE_ZEB1_212758_s_at_fs.png/250px-PBB_GE_ZEB1_212758_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/bc/PBB_GE_ZEB1_212764_at_fs.png/250px-PBB_GE_ZEB1_212764_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • DNA结合 • transcription corepressor activity • 转录共激活因子活性 • 鋅離子結合 • 转录因子结合 • chromatin binding • 金屬離子結合 • 血浆蛋白结合 • nucleic acid binding • DNA结合转录阻遏物活性,RNA聚合酶II特异性 • DNA结合转录因子活性 • E-box binding • DNA-binding transcription factor activity, RNA polymerase II-specific
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細胞組分 | • 轉錄調節複合物 • 细胞核 • 核质 • 细胞质基质
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生物學過程 | • pattern specification process • embryonic skeletal system morphogenesis • regulation of smooth muscle cell differentiation • animal organ development • 细胞分化 • semicircular canal morphogenesis • regulation of transcription, DNA-templated • regulation of transcription by RNA polymerase II • transcription, DNA-templated • 神經系統的發育 • regulation of transforming growth factor beta receptor signaling pathway • regulation of T cell differentiation in thymus • central nervous system development • 軟骨生成 • regulation of mesenchymal cell proliferation • embryonic camera-type eye morphogenesis • cochlea morphogenesis • 免疫反应 • embryonic morphogenesis • cellular response to amino acid stimulus • 細胞增殖 • negative regulation of epithelial cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • negative regulation of transcription, DNA-templated • positive regulation of neuron differentiation • negative regulation of transcription by RNA polymerase II • negative regulation of endothelial cell differentiation • cytokine-mediated signaling pathway
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096
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NM_030751 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678 |
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NM_011546 NM_001360981 NM_001360982 |
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蛋白序列 | NP_001121600 NP_001167564 NP_001167565 NP_001167566 NP_001167567
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NP_001310567 NP_001310570 NP_001310571 NP_001310572 NP_001310573 NP_001310574 NP_001310575 NP_001310576 NP_001310577 NP_001310578 NP_001310579 NP_001310580 NP_001310581 NP_001310582 NP_001310583 NP_001310584 NP_001310585 NP_001310586 NP_001310587 NP_001310588 NP_001310589 NP_001310590 NP_001310591 NP_001310592 NP_001310593 NP_001310594 NP_001310595 NP_001310600 NP_001310601 NP_001310602 NP_001310603 NP_001310604 NP_001310605 NP_001310606 NP_001310607 NP_110378 |
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NP_035676 NP_001347910 NP_001347911 |
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基因位置(UCSC) | Chr 10: 31.32 – 31.53 Mb | Chr 18: 5.59 – 5.78 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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