P63 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/97/Protein_TP73L_PDB_1rg6.png/250px-Protein_TP73L_PDB_1rg6.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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4A9Z、1RG6、2RMN、2Y9T、2Y9U、3QYM、3QYN、3US0、3US1、3US2、3ZY0、3ZY1 |
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識別號 |
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别名 | TP63;, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63 |
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外部ID | OMIM:603273 MGI:1330810 HomoloGene:31189 GeneCards:TP63 |
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相關疾病 |
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肺腺癌、lymphoblastic leukemia、肺癌、ADULT綜合徵、附肢-乳腺綜合徵、AEC綜合徵、split hand-foot malformation 2[1] |
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基因位置(小鼠) |
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![小鼠16号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/2/28/Ideogram_house_mouse_chromosome_16.svg/260px-Ideogram_house_mouse_chromosome_16.svg.png) | 染色体 | 小鼠16号染色体[3] |
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| 基因座 | 16 B1|16 17.37 cM | 起始 | 25,502,513 bp[3] |
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终止 | 25,710,852 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b8/PBB_GE_TP73L_209863_s_at_fs.png/250px-PBB_GE_TP73L_209863_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/4/47/PBB_GE_TP73L_211194_s_at_fs.png/250px-PBB_GE_TP73L_211194_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/PBB_GE_TP73L_211195_s_at_fs.png/250px-PBB_GE_TP73L_211195_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • DNA-binding transcription activator activity, RNA polymerase II-specific • 金屬離子結合 • damaged DNA binding • 血浆蛋白结合 • WW domain binding • double-stranded DNA binding • DNA结合 • sequence-specific DNA binding • 相同蛋白质结合 • chromatin binding • p53 binding • DNA结合转录因子活性 • MDM2/MDM4 family protein binding • DNA-binding transcription factor activity, RNA polymerase II-specific • protein domain specific binding
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細胞組分 | • 細胞質 • neuron projection • 细胞核 • 粗面内质网 • 轉錄調節複合物 • 核质 • 树突 • 線粒體 • 高尔基体 • 细胞质基质 • 大分子复合体
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生物學過程 | • pattern specification process • 骨骼系统的发生 • epithelial cell development • negative regulation of keratinocyte differentiation • epidermal cell division • anatomical structure formation involved in morphogenesis • prostate gland development • transcription by RNA polymerase II • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development • ectoderm and mesoderm interaction • cellular response to DNA damage stimulus • female genitalia morphogenesis • odontogenesis of dentin-containing tooth • prostatic bud formation • positive regulation of cell cycle G1/S phase transition • positive regulation of mesenchymal cell proliferation • 精子发生 • multicellular organism aging • smooth muscle tissue development • positive regulation of fibroblast apoptotic process • animal organ morphogenesis • hair follicle morphogenesis • positive regulation of Notch signaling pathway • 细胞凋亡 • 染色体重建 • regulation of transcription, DNA-templated • regulation of neuron apoptotic process • positive regulation of apoptotic signaling pathway • regulation of cysteine-type endopeptidase activity involved in apoptotic process • transcription, DNA-templated • embryonic limb morphogenesis • negative regulation of mesoderm development • epidermis development • post-anal tail morphogenesis • response to gamma radiation • protein homotetramerization • Notch信号通路 • hair follicle development • neuron apoptotic process • polarized epithelial cell differentiation • proximal/distal pattern formation • 细胞分化 • positive regulation of keratinocyte proliferation • skin morphogenesis • epithelial cell differentiation • 膀胱的发生 • cellular response to UV • establishment of planar polarity • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • protein tetramerization • keratinocyte proliferation • positive regulation of osteoblast differentiation • regulation of epidermal cell division • negative regulation of transcription, DNA-templated • negative regulation of cellular senescence • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • sympathetic nervous system development • establishment of skin barrier • morphogenesis of a polarized epithelium • keratinocyte differentiation • multicellular organism development • mitotic G1 DNA damage checkpoint signaling • cloacal septation • response to X-ray • positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of signal transduction by p53 class mediator • regulation of apoptotic process • 老化 • negative regulation of intracellular estrogen receptor signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of somatic stem cell population maintenance • 細胞增殖 • epidermal cell differentiation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • skin epidermis development • cranial skeletal system development • 发育过程
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | NM_001114978 NM_001114979 NM_001114980 NM_001114981 NM_001114982
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NM_003722 NM_001329144 NM_001329145 NM_001329146 NM_001329148 NM_001329149 NM_001329150 NM_001329964 |
| NM_001127259 NM_001127260 NM_001127261 NM_001127262 NM_001127263
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NM_001127264 NM_001127265 NM_011641 |
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蛋白序列 | NP_001108450 NP_001108451 NP_001108452 NP_001108453 NP_001108454
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NP_001316073 NP_001316074 NP_001316075 NP_001316077 NP_001316078 NP_001316079 NP_001316893 NP_003713 |
| NP_001120731 NP_001120732 NP_001120733 NP_001120734 NP_001120735
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NP_001120736 NP_001120737 NP_035771 |
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基因位置(UCSC) | Chr 3: 189.63 – 189.9 Mb | Chr 16: 25.5 – 25.71 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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