P73 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/6/6b/Protein_TP73_PDB_1cok.png/250px-Protein_TP73_PDB_1cok.png) |
已知的結構 |
---|
PDB | 直系同源搜索: PDBe RCSB |
---|
PDBID列表 |
---|
4GUQ、1COK、1DXS、2KBY、2MPS、2WQI、2WQJ、2WTT、2XWC、3VD0、3VD1、3VD2、4A63、4G82、4G83、4GUO |
|
|
識別號 |
---|
别名 | TP73;, P73, tumor protein p73, CILD47 |
---|
外部ID | OMIM:601990 MGI:1336991 HomoloGene:3960 GeneCards:TP73 |
---|
|
基因位置(小鼠) |
---|
![小鼠4号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | 染色体 | 小鼠4号染色体[2] |
---|
| 基因座 | 4 E2|4 83.79 cM | 起始 | 154,140,706 bp[2] |
---|
终止 | 154,224,665 bp[2] |
---|
|
RNA表达模式 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/4/4d/PBB_GE_TP73_220804_s_at_fs.png/250px-PBB_GE_TP73_220804_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
---|
分子功能 | • DNA结合 • sequence-specific DNA binding • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • chromatin binding • 金屬離子結合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • damaged DNA binding • 血浆蛋白结合 • 相同蛋白质结合 • protein kinase binding • p53 binding • DNA结合转录因子活性 • MDM2/MDM4 family protein binding • DNA-binding transcription factor activity, RNA polymerase II-specific
|
---|
細胞組分 | • 細胞質 • 高尔基体 • 細胞內膜結合細胞器 • 轉錄調節複合物 • 细胞连接 • 染色质 • 细胞核 • 線粒體 • 核质 • 细胞质基质
|
---|
生物學過程 | • negative regulation of neuron apoptotic process • positive regulation of oligodendrocyte differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • 肾的发生 • cellular response to UV • negative regulation of transcription by RNA polymerase II • protein tetramerization • transcription, DNA-templated • cellular response to DNA damage stimulus • mitotic G1 DNA damage checkpoint signaling • response to organonitrogen compound • intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitotic cell cycle • positive regulation of apoptotic process • 基因調節 • DNA错配修复 • 細胞週期 • negative regulation of cardiac muscle cell proliferation • viral process • negative regulation of JUN kinase activity • response to gamma radiation • response to X-ray • positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell population proliferation • 细胞凋亡 • regulation of signal transduction by p53 class mediator • transcription by RNA polymerase II • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of transcription, DNA-templated • regulation of hematopoietic stem cell differentiation
|
---|
Sources:Amigo / QuickGO |
|
直系同源 |
---|
物種 | 人類 | 小鼠 |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
mRNA序列 | NM_001126240 NM_001126241 NM_001126242 NM_001204184 NM_001204185
|
---|
NM_001204186 NM_001204187 NM_001204188 NM_001204189 NM_001204190 NM_001204191 NM_001204192 NM_005427 |
| |
---|
NM_001126330 NM_001126331 NM_011642 |
|
---|
蛋白序列 | NP_001119712 NP_001119713 NP_001119714 NP_001191113 NP_001191114
|
---|
NP_001191115 NP_001191116 NP_001191117 NP_001191118 NP_001191119 NP_001191120 NP_001191121 NP_005418 |
| |
---|
NP_001119802 NP_001119803 NP_035772 |
|
---|
基因位置(UCSC) | Chr 1: 3.65 – 3.74 Mb | Chr 4: 154.14 – 154.22 Mb |
---|
PubMed查找 | [3] | [4] |
---|
維基數據 |
|