NEUROD1 |
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已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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識別號 |
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别名 | NEUROD1;, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1, T2D |
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外部ID | OMIM:601724 MGI:1339708 HomoloGene:1871 GeneCards:NEUROD1 |
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基因位置(人类) |
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![2號染色體](//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png) | 染色体 | 2號染色體[1] |
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| 基因座 | 2q31.3 | 起始 | 181,668,295 bp[1] |
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终止 | 181,680,827 bp[1] |
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基因位置(小鼠) |
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![小鼠2号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | 染色体 | 小鼠2号染色体[2] |
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| 基因座 | 2 C3|2 47.58 cM | 起始 | 79,282,865 bp[2] |
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终止 | 79,287,095 bp[2] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b9/PBB_GE_NEUROD1_206282_at_fs.png/250px-PBB_GE_NEUROD1_206282_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • sequence-specific DNA binding • 转录共激活因子活性 • DNA结合 • protein dimerization activity • DNA结合转录因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • chromatin binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding • E-box binding • 血浆蛋白结合 • protein heterodimerization activity • double-stranded DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific
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細胞組分 | • 細胞質 • 胞內 • 核质 • RNA polymerase II transcription regulator complex • 细胞核
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生物學過程 | • positive regulation of transcription regulatory region DNA binding • regulation of neuron differentiation • 神经发生 • 细胞分化 • cell fate commitment • regulation of transcription, DNA-templated • pancreatic PP cell fate commitment • glucose homeostasis • regulation of insulin secretion • enteroendocrine cell differentiation • dentate gyrus development • signal transduction involved in regulation of gene expression • neuron development • insulin secretion • positive regulation of DNA-binding transcription factor activity • response to glucose • transcription by RNA polymerase II • embryonic organ morphogenesis • cerebellum development • transcription, DNA-templated • 神經系統的發育 • positive regulation of transcription, DNA-templated • multicellular organism development • hindbrain development • nucleocytoplasmic transport • positive regulation of neuron differentiation • positive regulation of cell differentiation • nitric oxide mediated signal transduction • positive regulation of apoptotic process • regulation of intestinal epithelial structure maintenance • 内耳的发生 • camera-type eye development • pancreatic A cell fate commitment • amacrine cell differentiation • negative regulation of type B pancreatic cell apoptotic process • cellular response to glucose stimulus • anterior/posterior pattern specification • endocrine pancreas development • positive regulation of transcription by RNA polymerase II • negative regulation of receptor signaling pathway via JAK-STAT
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 2: 181.67 – 181.68 Mb | Chr 2: 79.28 – 79.29 Mb |
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PubMed查找 | [3] | [4] |
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維基數據 |
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