SOX9 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Protein_SOX9_PDB_1S9M.png/250px-Protein_SOX9_PDB_1S9M.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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識別號 |
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别名 | SOX9;, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9 |
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外部ID | OMIM:608160 MGI:98371 HomoloGene:294 GeneCards:SOX9 |
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基因位置(小鼠) |
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![小鼠11号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | 染色体 | 小鼠11号染色体[2] |
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| 基因座 | 11 E2|11 77.27 cM | 起始 | 112,673,050 bp[2] |
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终止 | 112,678,586 bp[2] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/40/PBB_GE_SOX9_202935_s_at_fs.png/250px-PBB_GE_SOX9_202935_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/be/PBB_GE_SOX9_202936_s_at_fs.png/250px-PBB_GE_SOX9_202936_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • DNA结合转录因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • core promoter sequence-specific DNA binding • 蛋白激酶活性 • protein kinase A catalytic subunit binding • beta-catenin binding • pre-mRNA intronic binding • chromatin binding • 血浆蛋白结合 • DNA结合 • sequence-specific DNA binding • transcription cis-regulatory region binding • bHLH transcription factor binding • 核心启动子近端区域序列特异性DNA结合 • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding
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細胞組分 | • 细胞核 • 轉錄調節複合物 • 核质 • 大分子复合体
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生物學過程 | • 骨骼系统的发生 • cellular response to retinoic acid • bronchus cartilage development • positive regulation of protein phosphorylation • heart valve development • limb bud formation • positive regulation of protein catabolic process • regulation of transcription by RNA polymerase II • ureter morphogenesis • negative regulation of immune system process • chondrocyte development • positive regulation of cell proliferation involved in heart morphogenesis • oligodendrocyte differentiation • chondrocyte hypertrophy • prostate gland development • lung smooth muscle development • 乳腺发育 • negative regulation of ossification • negative regulation of photoreceptor cell differentiation • cellular response to mechanical stimulus • intrahepatic bile duct development • regulation of cell adhesion • negative regulation of chondrocyte differentiation • positive regulation of mesenchymal cell proliferation • astrocyte fate commitment • positive regulation of chondrocyte differentiation • 精子发生 • prostate gland morphogenesis • negative regulation of epithelial cell proliferation • lung epithelial cell differentiation • chondrocyte differentiation involved in endochondral bone morphogenesis • negative regulation of canonical Wnt signaling pathway • endocrine pancreas development • negative regulation of cell population proliferation • regulation of apoptotic process • cellular response to transforming growth factor beta stimulus • negative regulation of mesenchymal cell apoptotic process • 染色体重建 • negative regulation of myoblast differentiation • positive regulation of branching involved in ureteric bud morphogenesis • cell fate commitment • regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • 成骨作用 • regulation of cell proliferation involved in tissue homeostasis • ureter smooth muscle cell differentiation • ERK1 and ERK2 cascade • notochord development • positive regulation of epithelial cell migration • Sertoli cell differentiation • male sex determination • negative regulation of gene expression • transcription, DNA-templated • metanephric nephron tubule formation • positive regulation of transcription, DNA-templated • 心脏发育 • regulation of branching involved in lung morphogenesis • ureter urothelium development • branching involved in ureteric bud morphogenesis • 軟骨生成 • Harderian gland development • positive regulation of kidney development • central nervous system development • heart valve formation • positive regulation of cartilage development • tissue homeostasis • metanephric tubule development • negative regulation of biomineral tissue development • endochondral bone morphogenesis • trachea cartilage development • male germ-line sex determination • 泪腺的发生 • Notch信号通路 • hair follicle development • 细胞分化 • 输尿管的发生 • regulation of cell cycle process • male gonad development • positive regulation of epithelial cell proliferation • cell fate specification • intestinal epithelial structure maintenance • positive regulation of extracellular matrix assembly • extracellular matrix organization • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • Sertoli cell development • positive regulation of mesenchymal stem cell differentiation • retina development in camera-type eye • cellular response to interleukin-1 • 上皮-間充質轉換 • homeostasis of number of cells within a tissue • negative regulation of transcription, DNA-templated • cAMP-mediated signaling • cartilage condensation • positive regulation of male gonad development • nucleosome assembly • negative regulation of bone mineralization • morphogenesis of a branching epithelium • neural crest cell development • Akt/PKB信号通路 • somatic stem cell population maintenance • otic vesicle formation • otic vesicle development • endocardial cushion morphogenesis • cellular response to epidermal growth factor stimulus • positive regulation of epithelial cell differentiation • renal vesicle induction • positive regulation of gene expression • regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of cell population proliferation • heart valve morphogenesis • 细胞骨架组织 • cochlea morphogenesis • positive regulation of cell population proliferation • epithelial cell proliferation involved in prostatic bud elongation • retinal rod cell differentiation • protein localization to nucleus • regulation of cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • cellular response to heparin • negative regulation of epithelial cell differentiation • epithelial tube branching involved in lung morphogenesis • 訊息傳遞 • positive regulation of transcription by RNA polymerase II • negative regulation of pri-miRNA transcription by RNA polymerase II • chondrocyte differentiation • neural crest cell fate specification • cellular response to BMP stimulus • cell-cell adhesion • transcription initiation from RNA polymerase II promoter • protein-containing complex assembly • anterior head development • morphogenesis of an epithelium • aortic valve morphogenesis • 基因調節
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 17: 72.12 – 72.13 Mb | Chr 11: 112.67 – 112.68 Mb |
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PubMed查找 | [3] | [4] |
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維基數據 |
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